冠状动脉临界病变血管内超声检查参数与定量血流分数的相关性研究

目的探讨冠状动脉临界病变血管内超声(IVUS)检查参数与定量血流分数(QFR)的相关性。方法前瞻性连续入选2018年9月至2019年9月于同济大学附属东方医院接受QFR和IVUS检查的116例患者(117处冠状动脉临界病变)。根据QFR评估结果,将患者分为QFR≤0.80组(25处病变)和QFR>0.80组(92处病变),比较两组IVUS检查参数的差异。应用Poisson线性相关性分析以及受试者工作特征(ROC)曲线评估IVUS与QFR的相关性,应用logistic多元回归分析QFR≤0.80的预测因素。结果IVUS检查发现,QFR≤0.80组最小管腔面积(MLA)[(3.1±0.8)mm²比(3.6±1.1)mm²,P=0.040]、最小管腔直径(MLD)[(1.8±0.3)mm比(2.0±0.3)mm,P=0.012]显著小于QFR>0.80组,而斑块负荷[(73.5±5.6)%比(68.0±8.4)%,P=0.002]、面积狭窄率[(69.8±8.8)%比(63.8±9.8)%,P=0.007]、斑块偏心指数[(0.83±0.12)比(0.73±0.19),P=0.008]及回声消减斑块比例(52.0%比23.9%,P=0.003)显著高于QFR>0.80组,差异均有统计学意义。Poisson线性相关分析显示,MLA(r=0.259,P=0.005)、MLD(r=0.300,P=0.001)与QFR正相关,而斑块负荷(r=–0.357,P<0.001)以及斑块偏心指数(r=–0.247,P=0.008)与QFR负相关。logistic多因素回归分析表明斑块负荷>70%(OR 4.531,95%CI 1.443~14.222,P=0.010)和斑块偏心指数(OR 1.066,95%CI 1.014~1.121,P=0.012)为QFR≤0.80的独立预测因素。结论冠状动脉临界病变IVUS检查结果中斑块负荷>70%以及斑块偏心指数是QFR≤0.80的独立预测因子。     

藏族药“杂赤”的品种 基原与标准整理

藏族药（以下简称藏药）“杂赤”又称“杂赤确”“杂赤巴帽卡”等，产于四川、西藏等地，是一种治疗肝胆疾病的常用藏药。通过梳理查阅有关文献与标准发现，“杂赤”可以按正品、副品（替代品）和类同品分类，也可以按黑、白品种分类。其基原包含菊科12属约30种植物，涉及风毛菊属、苦荬菜属、小苦荬属及岩参属植物，各属植物功能主治基本相同。“杂赤”的品种整理、质量比较、药用历史和现状总结能够为“杂赤”的合理使用提供参考。     

一测多评法在中药质量控制中的应用及研究进展＊

一测多评法（quantitative analysis of multi-components by single marker，QAMS）已成熟应用于中药材、中药提取物及中成药领域等中药复杂体系的质量评价研究中，有效解决了因对照品缺乏而导致的多指标质控技术推广难问题。本文查阅近五年的国内外研究文献，重点总结了高效液相色谱、气相色谱和质谱等技术在QAMS法中药质量控制中的应用。高效液相色谱联用紫外检测器（UV）技术应用最为广泛，最适合于中药QAMS法定量，结果稳定、准确；而高效液相色谱联用蒸发光检测器在中药QAMS法应用中，其测定准确性和适用性仍然需进一步探索和验证。液质联用技术虽然具有灵敏度高、线性范围宽等优点，但易受仪器参数、基质效应等的影响。进一步发展HPLC-UV技术在中成药制剂质量评价中的应用，是QAMS法多成分定量值得关注的方向；探索LC-MS和GC技术在中药QAMS质量评价中的稳定性和普适性是未来将面临的挑战。     

Clinical assessment of oral malodor using autofluorescence of tongue coating

ObjectivesThe aim of this study was to evaluate whether a new method using quantitative light-induced fluorescence-digital (QLF-D) was appropriate for the diagnosis of oral malodor by quantifying the fluorescence of tongue coating.MethodsThis study examined 103 healthy subjects who have an oral malodor as a main complaint. The levels of oral malodor were measured by organoleptic scores (OLS) and volatile sulfur compound (VSC) levels. The fluorescent tongue coating images captured by QLF-D were quantified as the integrated fluorescence score (IF score) by multiplying the intensity and area of fluorescence. The correlations between the fluorescence parameters and OLS as well as VSC levels and the diagnostic accuracy of the IF score were evaluated.ResultsThe IF score of tongue coating showed a significant positive correlation with the OLS (r = 0.54, p < 0.01) and the VSC levels (r = 0.49, p < 0.01). This score was significantly differed with the level of oral malodor (p < 0.001), and its AUC was 0.72 in identifying the patient with definite oral malodor (≥OLS 2).ConclusionsA new method quantifying tongue coating fluorescence detected by QLF-D can be used to diagnose oral malodor and assess its severity in the clinical practice.     

Differences in the intensity of light-induced fluorescence emitted by resin composites

BackgroundThe aims of this study were to compare the intensities of fluorescence emitted by different resin composites as detected using quantitative light-induced fluorescence (QLF) technology, and to compare the fluorescence intensity contrast with the color contrast between a restored composite and the adjacent region of the tooth.MethodsSix brands of light-cured resin composites (shade A2) were investigated. The composites were used to prepare composite discs, and fill holes that had been prepared in extracted human teeth. White-light and fluorescence images of all specimens were obtained using a fluorescence camera based on QLF technology (QLF-D) and converted into 8-bit grayscale images. The fluorescence intensity of the discs as well as the fluorescence intensity contrast and the color contrast between the composite restoration and adjacent tooth region were calculated as grayscale levels.ResultsThe grayscale levels for the composite discs differed significantly with the brand (p < 0.001): DenFil (10.84 ± 0.35, mean ± SD), Filtek Z350 (58.28 ± 1.37), Premisa (156.94 ± 1.58), Grandio (177.20 ± 0.81), Charisma (207.05 ± 0.77), and Gradia direct posterior (211.52 ± 1.66). The difference in grayscale levels between a resin restoration and the adjacent tooth was significantly greater in fluorescence images for each brand than in white-light images, except for the Filtek Z350 (p < 0.05). However, the Filtek Z350 restoration was distinguishable from the adjacent tooth in a fluorescence image.ConclusionsThe intensities of fluorescence detected from the resin composites varied. The differences between the composite and adjacent tooth were greater for the fluorescence intensity contrast than for the colors observed in the white-light images.     

Assessment of In Vitro Dental Implant Primary Stability Using an Ultrasonic Method

Dental implants are used for oral rehabilitation. However, there remain risks of failure that depend on the implant stability. The objective of this study is to investigate whether quantitative ultrasound technique can be used to assess the amount of bone in contact with dental implants. Ten implants are first inserted in the bone samples. The 10 MHz ultrasonic response of each implant is measured using a dedicated device and an indicator I is derived based on the amplitude of the signal. Then, the implant is unscrewed by 2 π radians and the measurement is realized again. A statistical analysis of variance was carried out and revealed a significant effect of the amount of bone in contact with the implant on the values of I (p value < 10^?5). The results indicates the feasibility of quantitative ultrasound techniques to assess implant primary stability in vitro.     

超声造影定量评价肾血流灌注研究进展

目前肾脏CEUS不再局限于对局灶性病变的研究,日渐倾向于肾脏血流灌注的定量评价。CEUS定量分析技术可用于评估肾脏的血流灌注情况。CEUS具有更高的时间和空间分辨率,可较灵敏地检出肾脏血流及灌注改变,为评价肾脏血流灌注提供了一种便捷、无创、有效、重复性好的新方法。本文就CEUS定量评价肾灌注的原理、方法、临床应用及研究进展进行综述。     

骨肿瘤X线片定量分析系统中的形态参数测量

目的：用客观准确的定量分析方法取代医学科研和临床中传统的主观、不稳定的定性描述方法。方法：对多处骨肿瘤Ｘ光片进行准确的形态参数测量，与临床跟踪随访结果对照。结果：不同程度的骨肿瘤形态参数具有显著差异。结论：对形态参数的定量分析可以为骨肿瘤的早期诊断、治疗和预后提供了科学、可靠的依据。     

定量组织速度成像评价心肌梗死患者左心室舒张不同步性及整体舒张功能

目的探讨应用定量组织速度成像技术(QTVI)评价心肌梗死患者左心室非同步舒张运动的意义。方法获取60例心肌梗死患者及40例正常人的标准心尖部左室长轴、两腔和四腔观组织速度图像,离线分析左心室6个壁基底段、中间段和心尖段共18个位点及左心室各壁二尖瓣环的组织速度曲线,测量心电图QRS波起始点至各位点心肌舒张早期峰值速度(Ea)的时限(TQ-E)。计算同一节段6个壁间TQ-E的最大差值(Inter-ΔTQ-E)、同一壁内3个节段间TQ-E的最大差值(Intra-ΔTQ-E)及左心室18个位点间TQ-E的最大差值(Max-ΔTQ-E)。计算左心室各壁二尖瓣环Ea与舒张晚期峰值速度(Aa)比值的平均值(Ea/Aa′)。并利用常规超声心动图测定心肌梗死患者左室整体舒张末容积(EDV)、收缩末容积(ESV)、射血分数(LVEF)。结果与正常人相比,心肌梗死组EDV、ESV均明显升高,心肌梗死组EF明显降低,心肌梗死患者的Inter-ΔTQ-E、Intra-ΔTQ-E、Max-ΔTQ-E均明显延长,Ea/Aa′明显降低。心肌梗死患者中,Max-ΔTQ-E与Ea/Aa′均呈显著负相关;与EDV及ESV呈显著正相关;与EF呈显...